Researchers from the Institut Pasteur, CNRS and Vaccine Research Institute (ANRS/Inserm) recently shown that some effective antibodies recognize cells infected by the human immunodeficiency virus (HIV) and trigger their destruction by the immune system.
This discovery sheds new light on the mechanism of action of these specific antibodies, which are currently undergoing clinical trials. These findings are published in Nature Communications on March 3rd , 2016.
Using innovative technology, scientists from the Institut Pasteur and Inserm filmed in vivo the process by which an AIDS vaccine candidate, developed by the French Vaccine Research Institute and the ANRS, triggers the immune response. This previously unseen footage clearly shows how the vaccine recruits the immune cells needed to destroy infected cells.
These results, published in the journal Nature Medicine on December 21, 2015, shed new light on the mode of action and potential of this vaccine.