The VRI includes 150 researchers working on more than 40 international projects.

Preclinical models

Anne-Sophie Beignon

Her long-term interest lies in inducing protective immunity against infectious diseases with vaccines and in understanding the modes of action of vaccines. She has explored a strategy of non-invasive administration of vaccines through the transcutaneous route and the requirement in terms of Ag form and type of adjuvant as a PhD student at IBMC in Strasbourg under the supervision of Sylviane Muller (1998-2002).
Then she has studied the adjuvanticity of R848, a synthetic ligand of TLR7/8 involved in the detection of ssRNA viruses, on dendritic cells and decipher the molecular mechanisms of activation of plasmacytoid dendritic cells by HIV as a postdoctoral fellow at NYU; in NYC, USA, in the lab of Nina Bhardwaj (2002-2004).
She has then advanced the development of candidate vaccines based on lentiviral vectors against Plasmodium/malaria and HIV/AIDS, including with pre-clinical trials in non-human primates, to assess their protective efficacy at Institut Pasteur, Paris, as a postdoctoral fellow (2005-2007) and then as a 2nd (2007-2010) and then a 1st class CNRS Junior Scientist (since 2011) in the lab of Pierre Charneau. She has joined the lab headed by Roger Le Grand in 2012 where she lead a small research group. She focused her research on elucidating the modes of action of vaccines, especially the molecular and cellular mechanisms that govern the induction and maintenance of secondary memory responses after prime/boost immunizations.
She studies the dynamic of and interactions between innate and adaptive responses as a function of the number of immunizations and of the vaccine schedule using a systems vaccinology approach, and particularly, after MVA immunizations of in non-human primates in the context of the research performed at the VRI.